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Valeri BarsegovAssistant Professor 401A Olney Hall Department of Chemistry University of Massachusetts Lowell Lowell, MA 01854 email: Valeri_Barsegov@uml.edu phone: 978-934-3661 |
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Research |
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| My research involves theoretical and molecular dynamics simulation studies of diverse protein-protein interactions in biomolecules, and biomolecular complexes and aggregates. Current state of the art experiments on single molecules enable researchers to go beyound the endemble averaged picture and to analyze the entire distributions of the molecular characteristics. In my research group, we study the kinetics of formation/rupture of the hydrophobic interactions between linear hydrocarbon chains, such as hexadecane molecules, and between bulky hydrophobic solutes, such as fullerenes. We also study forced unfolding of proteins and protein tandems, and the forced rupture of protein-protein complexes and aggregates. Specific examples include the diubiquitin tandem, the tandem of fibrinogen and fibronectin, the knob-hole interaction in fibrin, and the Abeta amyloid fibril. To tackle these problems, we use all-atom molecular dynamics simulations, Langevin dynamics simulations, as well as theoretical models and advanced statistical data analyses. | ||||
Research highlights
Completed projects
TeachingBioinformaticsAdvanced Physical ChemistryFinancial support
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