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 Research

 

Our research focuses on the role of oxidative stress, inflammation and lipoproteins modification in atherosclerosis and related metabolic disorder syndromes.

We are also interested in clinical laboratory new method development and validation studies.

The goal of our current research is to outline the pathways responsible for the regulation of plasma lipoproteins and factors which are associated with increased risk for developing numerous metabolic disorders such as obesity, diabetes and cardiovascular diseases. Diet and life style, like exercise and sedentary life greatly impact lipoprotein metabolism and contribute to cardiovascular risk which is modulated by a group of inflammatory and oxidative stress markers.

We are also interested in the role of platelets and blood thrombosis factors in atherosclerosis.

Our lab also engages in development and validation of methods of potential diagnostic application.

Cell culture, animal models especially mouse lacking LDL receptors, dietary supplementation, molecular biology and chromatographic techniques are used in our lab.

Technical Expertise

Our Current Technical expertise includes but not limited to the following

 

Animal models:

  • Rabbits for atherosclerosis, and hemodynamic studies.
  •  Extensive experience with mice models for various diets, drugs and exercise experiments
  • Good experience in cell culture and molecular biology.

Instrumentation:

  • Great working experience with a variety of instruments and techniques.

Software:

  • Experince in a wide range of softwares

Center for Population Health

Core Laboratory

      Garelnabi Research Group is also the Core Lab for the Center for the Health Population.

    The laboratory core provides analysis of nutrients, biomarkers and clinical Laboratory measurements.

     Laboratory, located at the new UMass Lowell's Emerging Technologies and Innovation Center (ETIC).

Services include

  • Samples Collections, Processing, cataloging and storage.
  • Perform Basic and specialized Clinical Laboratory Analysis
  • Determining effect of any dietary intake on metabolic responses.
  • Investigating environmental factors on diseases.
  • Perform animal models microscopic and surgical procedures
  • Toxicity studies

Metabolic Biomarkers

  • Lipids & Lipids Metabolites
  • Vitamins
  • Inflammatory markers
  • Nutrients of interest
  • Oxidative stress mechanisms studies

 

                                                   Clinical Chemistry Methods

Method verifications and Validation Studies

The Core Lab can also perform new and existing method verifications and validations studies for 510K submission.

 

  • Methods validations
  • Point of care testing instruments validation

Quality Assurances

*Core Lab follow GLP and specific available QA methods on analytes of interest.
*Follow commercial manufacturer QA regimen.
*The Clinical & Laboratory Standards Institute (CLSI) approved guidelines as it apply.

Team

  • Former students

 

Undergraduate students

 

Rhea Cabrera

       

Andrew Carvalho

 

Eden Hok

Students completed undergraduate senior research projects:

The following undergraduate students have completed research training/projects in Garelnabi Research Lab:

    1. Mindasari Daniar
    2. Tyler Sullivan
    3. Sryesross Chhim
    4. Andrew E Carvalho
    5. Anthony Rodrigues
    6. Eden Hok
    7. Eric Bresnahan
    8. John Mensah
    9. Johnson Seng-Hy Lor
    10. Kassandre Danger
    11. Kim Sot
    12. Megan Rebello
    13. Michelle Ntori
    14. Nancy Sok
    15. Naseeha B Jamil
    16. Priscilla Stephens
    17. Rhea Mae Cabrera
    18. Romesa Hannan
    19. Samantha Zdanowicz
    20. Shannon Dizer
    21. Sung Chul Ho
    22. Thavaleak Prum
    23. Thuy Trang T Tran
    24. Yanick Dadaille

  • Graduate Master Students (Completed):

    1. Aza Elshiekh Ibrahim (May 2017)
    2. Ahmed Alkhadra (May 2017)
    3. Nadia Alghamdi (May 2017)
    4. Sryesross Chhim (December 2016)
    5. Hatim Abolula (May 2016)
    6. Stacey Dybel (December 2015)
    7. Dhuha Fawaz H Alsayrafi (December 2015)
    8. Zahra Mazhar (December 2015)
    9. Tong Wu (May, 2015)
    10. Kevin Michael Ho (2014-2015)
    11. Derek P Silva (2014-2015)
    12. Emir Daloty (2013-2014)
    13. Fessehaie Nugusse (2013)
    14. Andrew Hughes (2012-2013)
    15. Jun Jin (2012)
    16. Fei Chai (2012)
    17. Anupriya Sing (2011)
    18. Kenton Lor MS (spring 2011)
    19. Premlatha Jagadeesan (2010-2011)

Anupriya Singh MS (spring 2011)

 

Rsearch Group photo 2010

 

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                                                                                                    Graduated Lab Members

Halleh Mahini

Doctorate of Philosophy in Biomedical Engineering and Bitechnology, May 2015.

 

 

Education:

 

PhD Biomedical Engineering & Biotechnology, May 2015

 

MS Biomedical Engineering & Biotechnology  2011

University of Massachusetts Lowell

 

B.S. Biological Sciences, 2008

University of Massachusetts Lowell

   Halleh Mahini presenting her work at the American Heart Association meeting in Chicago 2013

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Current Master Students 2016- :

Aza Elshiekh Ibrahim

Ahmed Alkhadra

Nadia Alghamdi

Osama Ahmed

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Doctoral Students

 

Chinedu C. Ochin, MBBS, MS.,

EDUCATION

University of Massachusetts-Lowell

PhD Candidate (Biomedical Engineering and Biotechnology)   (Anticipated) 2017/18

MS (Biomedical Engineering and Biotechnology)                        May 2014

Ebonyi State University-Nigeria  MBBS (Medicine and Surgery)    Sept 2006      

                                   

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Awards and Recognitions

Undergraduate students who received Robert Niclosi Research Awards:

  • Andrew Carvalho 2012
  • Shannon Dizer 2013
  • Eric Bresnahan 2014
  • Samantha Zdanowicz 2015

Graduate students who received graduate Research Awards:

  • Kenton Lor MS 2011
  • Jun Jin MS 2012
  • Dhuha Fawaz H Alsayrafi 2016
  • Sryesross Chhim 2017

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Recently Published Images from the Lab

                                                  Clin Biochem. 2013 Jan;46(1-2):12-9.

 

 

Fig. (2). Possible mechanism of Lp(a) in stroke. Shows a simplified schematic of the possible connection between Lp(a) and stroke. The
LPA gene gets expressed and then the Lp(a) protein, gets assembled with ApoA1 and apoB either inside cells or outside in the plasma. The
assembled Lp(a) circulates in the plasma and the small sized Lp(a) particles can bind certain Blood vessel proteins and clump together; Lp
(a) inhibits plasmin which mediated the prevention of blood clot formation. Cardiovasc Hematol Disord Drug Targets. 2017;17(1):64-72.